Heart-specific Rpd3 downregulation enhances cardiac function and longevity

Heart-specific Rpd3 downregulation enhances cardiac function and longevity

Downregulation of Rpd3, a homologue of mammalian Histone Deacetylase 1 (HDAC1), extends lifespan in Drosophila melanogaster. Once revealed that long-lived fruit flies exhibit limited cardiac decline, we investigated whether Rpd3 downregulation would improve stress resistance and/or lifespan when tar...

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Bibliographic Details
Main Authors: Kopp, Zachary A., Hsieh, Jo-Lin, Li, Andrew, Wang, William, Bhatt, Dhelni T., Lee, Angela, Kim, Sae Yeon, Fan, David, Shah, Veevek, Siddiqui, Emaad, Ragam, Radhika, Park, Kristen, Ardeshna, Dev, Park, Kunwoo, Wu, Rachel, Parikh, Hardik, Parikh, Ayush, Lin, Yuh-Ru, Park, Yongkyu
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600623/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600623/

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