Targeting the Mitotic Catastrophe Signaling Pathway in Cancer
Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic cata...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600505/ |
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pubmed-46005052015-10-21 Targeting the Mitotic Catastrophe Signaling Pathway in Cancer Mc Gee, Margaret M. Review Article Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour development. Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents. Yet, despite its importance in tumour prevention and treatment, the molecular mechanism of mitotic catastrophe is not well understood. A better understanding of the signals that determine cell fate following failed or defective mitosis will reveal new opportunities to selectively target and enhance the programme for therapeutic benefit and reveal biomarkers to predict patient response. This review is focused on the molecular mechanism of mitotic catastrophe induction and signalling and highlights current strategies to exploit the process in cancer therapy. Hindawi Publishing Corporation 2015 2015-09-27 /pmc/articles/PMC4600505/ /pubmed/26491220 http://dx.doi.org/10.1155/2015/146282 Text en Copyright © 2015 Margaret M. Mc Gee. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mc Gee, Margaret M. |
| spellingShingle |
Mc Gee, Margaret M. Targeting the Mitotic Catastrophe Signaling Pathway in Cancer |
| author_facet |
Mc Gee, Margaret M. |
| author_sort |
Mc Gee, Margaret M. |
| title |
Targeting the Mitotic Catastrophe Signaling Pathway in Cancer |
| title_short |
Targeting the Mitotic Catastrophe Signaling Pathway in Cancer |
| title_full |
Targeting the Mitotic Catastrophe Signaling Pathway in Cancer |
| title_fullStr |
Targeting the Mitotic Catastrophe Signaling Pathway in Cancer |
| title_full_unstemmed |
Targeting the Mitotic Catastrophe Signaling Pathway in Cancer |
| title_sort |
targeting the mitotic catastrophe signaling pathway in cancer |
| description |
Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour development. Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents. Yet, despite its importance in tumour prevention and treatment, the molecular mechanism of mitotic catastrophe is not well understood. A better understanding of the signals that determine cell fate following failed or defective mitosis will reveal new opportunities to selectively target and enhance the programme for therapeutic benefit and reveal biomarkers to predict patient response. This review is focused on the molecular mechanism of mitotic catastrophe induction and signalling and highlights current strategies to exploit the process in cancer therapy. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600505/ |
| _version_ |
1613486200914444288 |