A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement

Cell migration is driven by the establishment of disparity between the cortical properties of the softer front and the more rigid rear allowing front extension and actomyosin-based rear contraction. However, how the cortical actin meshwork in the rear is generated remains elusive. Here we identify t...

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Bibliographic Details
Main Authors: Ramalingam, Nagendran, Franke, Christof, Jaschinski, Evelin, Winterhoff, Moritz, Lu, Yao, Brühmann, Stefan, Junemann, Alexander, Meier, Helena, Noegel, Angelika A., Weber, Igor, Zhao, Hongxia, Merkel, Rudolf, Schleicher, Michael, Faix, Jan
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598863/