Discovery of Novel Anti-prion Compounds Using In Silico and In Vitro Approaches

Discovery of Novel Anti-prion Compounds Using In Silico and In Vitro Approaches

Prion diseases are associated with the conformational conversion of the physiological form of cellular prion protein (PrPC) to the pathogenic form, PrPSc. Compounds that inhibit this process by blocking conversion to the PrPSc could provide useful anti-prion therapies. However, no suitable drugs hav...

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Bibliographic Details
Main Authors: Hyeon, Jae Wook, Choi, Jiwon, Kim, Su Yeon, Govindaraj, Rajiv Gandhi, Jam Hwang, Kyu, Lee, Yeong Seon, An, Seong Soo A., Lee, Myung Koo, Joung, Jong Young, No, Kyoung Tai, Lee, Jeongmin
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598813/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598813/

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