The antiviral drug ganciclovir does not inhibit microglial proliferation and activation

Ganciclovir is effective in the treatment of human infections with viruses of the Herpesviridae family. Beside antiviral properties, recently ganciclovir was described to inhibit microglial proliferation and disease severity of experimental autoimmune encephalomyelitis, an inflammatory model of mult...

Full description

Bibliographic Details
Main Authors:	Skripuletz, Thomas, Salinas Tejedor, Laura, Prajeeth, Chittappen K., Hansmann, Florian, Chhatbar, Chintan, Kucman, Valeria, Zhang, Ning, Raddatz, Barbara B., Detje, Claudia N., Sühs, Kurt-Wolfram, Pul, Refik, Gudi, Viktoria, Kalinke, Ulrich, Baumgärtner, Wolfgang, Stangel, Martin
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597339/

id	pubmed-4597339
recordtype	oai_dc
spelling	pubmed-45973392015-10-13 The antiviral drug ganciclovir does not inhibit microglial proliferation and activation Skripuletz, Thomas Salinas Tejedor, Laura Prajeeth, Chittappen K. Hansmann, Florian Chhatbar, Chintan Kucman, Valeria Zhang, Ning Raddatz, Barbara B. Detje, Claudia N. Sühs, Kurt-Wolfram Pul, Refik Gudi, Viktoria Kalinke, Ulrich Baumgärtner, Wolfgang Stangel, Martin Article Ganciclovir is effective in the treatment of human infections with viruses of the Herpesviridae family. Beside antiviral properties, recently ganciclovir was described to inhibit microglial proliferation and disease severity of experimental autoimmune encephalomyelitis, an inflammatory model of multiple sclerosis. Microglial activation and proliferation are main characteristics of neuroinflammatory CNS diseases and inhibition of microglial functions might be beneficial in autoimmune diseases, or detrimental in infectious diseases. The objective of this study was to determine potential inhibitory effects of ganciclovir in three different murine animal models of CNS neuroinflammation in which microglia play an important role: Theiler´s murine encephalomyelitis, the cuprizone model of de- and remyelination, and the vesicular stomatitis virus encephalitis model. In addition, in vitro experiments with microglial cultures were performed to test the hypothesis that ganciclovir inhibits microglial proliferation. In all three animal models, neither microglial proliferation or recruitment nor disease activity was changed by ganciclovir. In vitro experiments confirmed that microglial proliferation was not affected by ganciclovir. In conclusion, our results show that the antiviral drug ganciclovir does not inhibit microglial activation and proliferation in the murine CNS. Nature Publishing Group 2015-10-08 /pmc/articles/PMC4597339/ /pubmed/26447351 http://dx.doi.org/10.1038/srep14935 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Skripuletz, Thomas Salinas Tejedor, Laura Prajeeth, Chittappen K. Hansmann, Florian Chhatbar, Chintan Kucman, Valeria Zhang, Ning Raddatz, Barbara B. Detje, Claudia N. Sühs, Kurt-Wolfram Pul, Refik Gudi, Viktoria Kalinke, Ulrich Baumgärtner, Wolfgang Stangel, Martin
spellingShingle	Skripuletz, Thomas Salinas Tejedor, Laura Prajeeth, Chittappen K. Hansmann, Florian Chhatbar, Chintan Kucman, Valeria Zhang, Ning Raddatz, Barbara B. Detje, Claudia N. Sühs, Kurt-Wolfram Pul, Refik Gudi, Viktoria Kalinke, Ulrich Baumgärtner, Wolfgang Stangel, Martin The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
author_facet	Skripuletz, Thomas Salinas Tejedor, Laura Prajeeth, Chittappen K. Hansmann, Florian Chhatbar, Chintan Kucman, Valeria Zhang, Ning Raddatz, Barbara B. Detje, Claudia N. Sühs, Kurt-Wolfram Pul, Refik Gudi, Viktoria Kalinke, Ulrich Baumgärtner, Wolfgang Stangel, Martin
author_sort	Skripuletz, Thomas
title	The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
title_short	The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
title_full	The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
title_fullStr	The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
title_full_unstemmed	The antiviral drug ganciclovir does not inhibit microglial proliferation and activation
title_sort	antiviral drug ganciclovir does not inhibit microglial proliferation and activation
description	Ganciclovir is effective in the treatment of human infections with viruses of the Herpesviridae family. Beside antiviral properties, recently ganciclovir was described to inhibit microglial proliferation and disease severity of experimental autoimmune encephalomyelitis, an inflammatory model of multiple sclerosis. Microglial activation and proliferation are main characteristics of neuroinflammatory CNS diseases and inhibition of microglial functions might be beneficial in autoimmune diseases, or detrimental in infectious diseases. The objective of this study was to determine potential inhibitory effects of ganciclovir in three different murine animal models of CNS neuroinflammation in which microglia play an important role: Theiler´s murine encephalomyelitis, the cuprizone model of de- and remyelination, and the vesicular stomatitis virus encephalitis model. In addition, in vitro experiments with microglial cultures were performed to test the hypothesis that ganciclovir inhibits microglial proliferation. In all three animal models, neither microglial proliferation or recruitment nor disease activity was changed by ganciclovir. In vitro experiments confirmed that microglial proliferation was not affected by ganciclovir. In conclusion, our results show that the antiviral drug ganciclovir does not inhibit microglial activation and proliferation in the murine CNS.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597339/
_version_	1613484937413918720

The antiviral drug ganciclovir does not inhibit microglial proliferation and activation

Similar Items