Inflammation Induces TDP-43 Mislocalization and Aggregation

Inflammation Induces TDP-43 Mislocalization and Aggregation

TAR DNA-binding protein 43 (TDP-43) is a major component in aggregates of ubiquitinated proteins in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we report that lipopolysaccharide (LPS)-induced inflammation can promote TDP-43 mislocalization and aggregation....

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Bibliographic Details
Main Authors: Correia, Ana Sofia, Patel, Priyanka, Dutta, Kallol, Julien, Jean-Pierre
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596857/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596857/

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