Network structure of brain atrophy in de novo Parkinson's disease

We mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified...

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Main Authors:	Zeighami, Yashar, Ulla, Miguel, Iturria-Medina, Yasser, Dadar, Mahsa, Zhang, Yu, Larcher, Kevin Michel-Herve, Fonov, Vladimir, Evans, Alan C, Collins, D Louis, Dagher, Alain
Format:	Online
Language:	English
Published:	eLife Sciences Publications, Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596689/

id	pubmed-4596689
recordtype	oai_dc
spelling	pubmed-45966892015-10-08 Network structure of brain atrophy in de novo Parkinson's disease Zeighami, Yashar Ulla, Miguel Iturria-Medina, Yasser Dadar, Mahsa Zhang, Yu Larcher, Kevin Michel-Herve Fonov, Vladimir Evans, Alan C Collins, D Louis Dagher, Alain Neuroscience We mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified PD-specific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions. The degree of atrophy reflected clinical measures of disease severity. The spatial pattern of atrophy demonstrated overlap with intrinsic networks present in healthy brain, as derived from functional MRI. Moreover, the degree of atrophy in each brain region reflected its functional and anatomical proximity to a presumed disease epicenter in the substantia nigra, compatible with a trans-neuronal spread of the disease. These results support a network-spread mechanism in PD. Finally, the atrophy pattern in PD was also seen in healthy aging, where it also correlated with the loss of striatal dopaminergic innervation. eLife Sciences Publications, Ltd 2015-09-07 /pmc/articles/PMC4596689/ /pubmed/26344547 http://dx.doi.org/10.7554/eLife.08440 Text en © 2015, Zeighami et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zeighami, Yashar Ulla, Miguel Iturria-Medina, Yasser Dadar, Mahsa Zhang, Yu Larcher, Kevin Michel-Herve Fonov, Vladimir Evans, Alan C Collins, D Louis Dagher, Alain
spellingShingle	Zeighami, Yashar Ulla, Miguel Iturria-Medina, Yasser Dadar, Mahsa Zhang, Yu Larcher, Kevin Michel-Herve Fonov, Vladimir Evans, Alan C Collins, D Louis Dagher, Alain Network structure of brain atrophy in de novo Parkinson's disease
author_facet	Zeighami, Yashar Ulla, Miguel Iturria-Medina, Yasser Dadar, Mahsa Zhang, Yu Larcher, Kevin Michel-Herve Fonov, Vladimir Evans, Alan C Collins, D Louis Dagher, Alain
author_sort	Zeighami, Yashar
title	Network structure of brain atrophy in de novo Parkinson's disease
title_short	Network structure of brain atrophy in de novo Parkinson's disease
title_full	Network structure of brain atrophy in de novo Parkinson's disease
title_fullStr	Network structure of brain atrophy in de novo Parkinson's disease
title_full_unstemmed	Network structure of brain atrophy in de novo Parkinson's disease
title_sort	network structure of brain atrophy in de novo parkinson's disease
description	We mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified PD-specific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions. The degree of atrophy reflected clinical measures of disease severity. The spatial pattern of atrophy demonstrated overlap with intrinsic networks present in healthy brain, as derived from functional MRI. Moreover, the degree of atrophy in each brain region reflected its functional and anatomical proximity to a presumed disease epicenter in the substantia nigra, compatible with a trans-neuronal spread of the disease. These results support a network-spread mechanism in PD. Finally, the atrophy pattern in PD was also seen in healthy aging, where it also correlated with the loss of striatal dopaminergic innervation.
publisher	eLife Sciences Publications, Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596689/
_version_	1613484681693495296

Network structure of brain atrophy in de novo Parkinson's disease

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