Squamous Cell Lung Cancer Associated With Systemic Sclerosis

We here describe a 50-year-old woman diagnosed with squamous cell lung cancer (SqLC) with underlying interstitial lung disease (ILD) 14 years after a diagnosis of systemic sclerosis (SSc). We reviewed the literature and collected 21 well-documented cases with SqLC associated with SSc including the p...

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Main Authors:	Kanaji, Nobuhiro, Okuda, Masaya, Dobashi, Hiroaki, Kameda, Tomohiro, Tadokoro, Akira, Wakiya, Risa, Kadowaki, Norimitsu, Bandoh, Shuji
Format:	Online
Language:	English
Published:	Elmer Press 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596273/

id	pubmed-4596273
recordtype	oai_dc
spelling	pubmed-45962732015-10-21 Squamous Cell Lung Cancer Associated With Systemic Sclerosis Kanaji, Nobuhiro Okuda, Masaya Dobashi, Hiroaki Kameda, Tomohiro Tadokoro, Akira Wakiya, Risa Kadowaki, Norimitsu Bandoh, Shuji Case Report We here describe a 50-year-old woman diagnosed with squamous cell lung cancer (SqLC) with underlying interstitial lung disease (ILD) 14 years after a diagnosis of systemic sclerosis (SSc). We reviewed the literature and collected 21 well-documented cases with SqLC associated with SSc including the present case. Several characteristics of SqLC associated with SSc have been found. First, the average age at diagnosis of SqLC is 57 years, which is much younger than that reported for patients without SSc. Second, SqLC could occur even in never or light smokers, although SqLC usually has a strong association with smoking history. Third, two-thirds of the available cases have ILD. In addition, SqLC developed in the area of ILD in most cases with ILD. Fourth, SqLC generally occurs after a long period from the diagnosis of SSc; the average of this interval reaches 12 years. It would be helpful to know these features so that physicians follow up and treat SSc patients adequately. Elmer Press 2015-11 2015-09-25 /pmc/articles/PMC4596273/ /pubmed/26491504 http://dx.doi.org/10.14740/jocmr2313w Text en Copyright 2015, Kanaji et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kanaji, Nobuhiro Okuda, Masaya Dobashi, Hiroaki Kameda, Tomohiro Tadokoro, Akira Wakiya, Risa Kadowaki, Norimitsu Bandoh, Shuji
spellingShingle	Kanaji, Nobuhiro Okuda, Masaya Dobashi, Hiroaki Kameda, Tomohiro Tadokoro, Akira Wakiya, Risa Kadowaki, Norimitsu Bandoh, Shuji Squamous Cell Lung Cancer Associated With Systemic Sclerosis
author_facet	Kanaji, Nobuhiro Okuda, Masaya Dobashi, Hiroaki Kameda, Tomohiro Tadokoro, Akira Wakiya, Risa Kadowaki, Norimitsu Bandoh, Shuji
author_sort	Kanaji, Nobuhiro
title	Squamous Cell Lung Cancer Associated With Systemic Sclerosis
title_short	Squamous Cell Lung Cancer Associated With Systemic Sclerosis
title_full	Squamous Cell Lung Cancer Associated With Systemic Sclerosis
title_fullStr	Squamous Cell Lung Cancer Associated With Systemic Sclerosis
title_full_unstemmed	Squamous Cell Lung Cancer Associated With Systemic Sclerosis
title_sort	squamous cell lung cancer associated with systemic sclerosis
description	We here describe a 50-year-old woman diagnosed with squamous cell lung cancer (SqLC) with underlying interstitial lung disease (ILD) 14 years after a diagnosis of systemic sclerosis (SSc). We reviewed the literature and collected 21 well-documented cases with SqLC associated with SSc including the present case. Several characteristics of SqLC associated with SSc have been found. First, the average age at diagnosis of SqLC is 57 years, which is much younger than that reported for patients without SSc. Second, SqLC could occur even in never or light smokers, although SqLC usually has a strong association with smoking history. Third, two-thirds of the available cases have ILD. In addition, SqLC developed in the area of ILD in most cases with ILD. Fourth, SqLC generally occurs after a long period from the diagnosis of SSc; the average of this interval reaches 12 years. It would be helpful to know these features so that physicians follow up and treat SSc patients adequately.
publisher	Elmer Press
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596273/
_version_	1613484517103763456

Squamous Cell Lung Cancer Associated With Systemic Sclerosis

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