High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis

Maternal obesity is associated with lower basal plasma cortisol levels and increased risk of postpartum psychiatric disorders. Given that both obesity and the peripartum period are characterized by an imbalance between adrenocorticotropic hormone (ACTH) and cortisol, we hypothesized that the adrenal...

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Main Authors:	Perani, Clara V., Neumann, Inga D., Reber, Stefan O., Slattery, David A.
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595833/

id	pubmed-4595833
recordtype	oai_dc
spelling	pubmed-45958332015-10-13 High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis Perani, Clara V. Neumann, Inga D. Reber, Stefan O. Slattery, David A. Article Maternal obesity is associated with lower basal plasma cortisol levels and increased risk of postpartum psychiatric disorders. Given that both obesity and the peripartum period are characterized by an imbalance between adrenocorticotropic hormone (ACTH) and cortisol, we hypothesized that the adrenal glands undergo peripartum-associated plasticity and that such changes would be prevented by a high-fat diet (HFD). Here, we demonstrate substantial peripartum adrenal gland plasticity in the pathways involved in cholesterol supply for steroidogenesis in female rats. In detail, the receptors involved in plasma lipid uptake, low density lipoprotein (LDL) receptor (LDLR) and scavenger receptor class B type 1 (SRB1), are elevated, intra-adrenal cholesterol stores are depleted, and a key enzyme in de novo cholesterol synthesis, hydroxymethylglutaryl coenzyme A reductase (HMGCR), is downregulated; particularly at mid-lactation. HFD prevented the lactation-associated anxiolysis, basal hypercorticism, and exaggerated the corticosterone response to ACTH. Moreover, we show that HFD prevented the downregulation of adrenal cholesterol stores and HMGCR expression, and LDLR upregulation at mid-lactation. These findings show that the adrenal gland is an important regulator of peripartum-associated HPA axis plasticity and that HFD has maladaptive consequences for the mother, partly by preventing these neuroendocrine and also behavioural changes. Nature Publishing Group 2015-10-07 /pmc/articles/PMC4595833/ /pubmed/26442440 http://dx.doi.org/10.1038/srep14821 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Perani, Clara V. Neumann, Inga D. Reber, Stefan O. Slattery, David A.
spellingShingle	Perani, Clara V. Neumann, Inga D. Reber, Stefan O. Slattery, David A. High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
author_facet	Perani, Clara V. Neumann, Inga D. Reber, Stefan O. Slattery, David A.
author_sort	Perani, Clara V.
title	High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
title_short	High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
title_full	High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
title_fullStr	High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
title_full_unstemmed	High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
title_sort	high-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
description	Maternal obesity is associated with lower basal plasma cortisol levels and increased risk of postpartum psychiatric disorders. Given that both obesity and the peripartum period are characterized by an imbalance between adrenocorticotropic hormone (ACTH) and cortisol, we hypothesized that the adrenal glands undergo peripartum-associated plasticity and that such changes would be prevented by a high-fat diet (HFD). Here, we demonstrate substantial peripartum adrenal gland plasticity in the pathways involved in cholesterol supply for steroidogenesis in female rats. In detail, the receptors involved in plasma lipid uptake, low density lipoprotein (LDL) receptor (LDLR) and scavenger receptor class B type 1 (SRB1), are elevated, intra-adrenal cholesterol stores are depleted, and a key enzyme in de novo cholesterol synthesis, hydroxymethylglutaryl coenzyme A reductase (HMGCR), is downregulated; particularly at mid-lactation. HFD prevented the lactation-associated anxiolysis, basal hypercorticism, and exaggerated the corticosterone response to ACTH. Moreover, we show that HFD prevented the downregulation of adrenal cholesterol stores and HMGCR expression, and LDLR upregulation at mid-lactation. These findings show that the adrenal gland is an important regulator of peripartum-associated HPA axis plasticity and that HFD has maladaptive consequences for the mother, partly by preventing these neuroendocrine and also behavioural changes.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595833/
_version_	1613484382738186240

High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis

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