Pathways of allosteric regulation in Hsp70 chaperones
Central to the protein folding activity of Hsp70 chaperones is their ability to interact with protein substrates in an ATP-controlled manner, which relies on allosteric regulation between their nucleotide-binding (NBD) and substrate-binding domains (SBD). Here we dissect this mechanism by analysing...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Pub. Group
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595643/ |