FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

The Fanconi anemia (FA)-BRCA pathway mediates repair of DNA interstrand crosslinks. The FA core complex, a multi-subunit ubiquitin ligase, participates in the detection of DNA lesions and monoubiquitinates two downstream FA proteins, FANCD2 and FANCI (or the ID complex). However, the regulation of t...

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Bibliographic Details
Main Authors: Castella, Maria, Jacquemont, Celine, Thompson, Elizabeth L., Yeo, Jung Eun, Cheung, Ronald S., Huang, Jen-Wei, Sobeck, Alexandra, Hendrickson, Eric A., Taniguchi, Toshiyasu
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592014/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592014/

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