Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse

We report the first case of methicillin-resistant Staphylococcus aureus (MRSA) keratitis in a racehorse. A 5-year-old mare developed punctate keratitis after racing. The corneal ulcer continued to expand despite ophthalmic antimicrobial therapy. On day 6, a conjunctival graft surgery was performed....

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Main Authors:	KURODA, Taisuke, KINOSHITA, Yuta, NIWA, Hidekazu, MIZOBE, Fumiaki, UENO, Takanori, KUWANO, Atsutoshi, HATAZOE, Takashi, HOBO, Seiji
Format:	Online
Language:	English
Published:	The Japanese Society of Equine Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591416/

id	pubmed-4591416
recordtype	oai_dc
spelling	pubmed-45914162015-10-02 Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse KURODA, Taisuke KINOSHITA, Yuta NIWA, Hidekazu MIZOBE, Fumiaki UENO, Takanori KUWANO, Atsutoshi HATAZOE, Takashi HOBO, Seiji Note We report the first case of methicillin-resistant Staphylococcus aureus (MRSA) keratitis in a racehorse. A 5-year-old mare developed punctate keratitis after racing. The corneal ulcer continued to expand despite ophthalmic antimicrobial therapy. On day 6, a conjunctival graft surgery was performed. The mare was euthanized, following colitis and laminitis development on day 10. MRSA was isolated from the corneal swab taken at the time of euthanasia. Immunohistochemical analysis demonstrated gram-positive and anti-S. aureus monoclonal antibody-positive cocci infiltration of the corneal stroma; and a diagnosis of MRSA ulcerative keratitis was made. An ophthalmic antimicrobial against the isolated MRSA did not improve the ocular lesion. The MRSA strain was found to be staphylococcal cassette chromosome mec type II, a strain frequently isolated from humans in Japan. The Japanese Society of Equine Science 2015-09-30 2015 /pmc/articles/PMC4591416/ /pubmed/26435683 http://dx.doi.org/10.1294/jes.26.95 Text en 2015 The Japanese Society of Equine Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	KURODA, Taisuke KINOSHITA, Yuta NIWA, Hidekazu MIZOBE, Fumiaki UENO, Takanori KUWANO, Atsutoshi HATAZOE, Takashi HOBO, Seiji
spellingShingle	KURODA, Taisuke KINOSHITA, Yuta NIWA, Hidekazu MIZOBE, Fumiaki UENO, Takanori KUWANO, Atsutoshi HATAZOE, Takashi HOBO, Seiji Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse
author_facet	KURODA, Taisuke KINOSHITA, Yuta NIWA, Hidekazu MIZOBE, Fumiaki UENO, Takanori KUWANO, Atsutoshi HATAZOE, Takashi HOBO, Seiji
author_sort	KURODA, Taisuke
title	Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse
title_short	Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse
title_full	Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse
title_fullStr	Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse
title_full_unstemmed	Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse
title_sort	methicillin-resistant staphylococcus aureus ulcerative keratitis in a thoroughbred racehorse
description	We report the first case of methicillin-resistant Staphylococcus aureus (MRSA) keratitis in a racehorse. A 5-year-old mare developed punctate keratitis after racing. The corneal ulcer continued to expand despite ophthalmic antimicrobial therapy. On day 6, a conjunctival graft surgery was performed. The mare was euthanized, following colitis and laminitis development on day 10. MRSA was isolated from the corneal swab taken at the time of euthanasia. Immunohistochemical analysis demonstrated gram-positive and anti-S. aureus monoclonal antibody-positive cocci infiltration of the corneal stroma; and a diagnosis of MRSA ulcerative keratitis was made. An ophthalmic antimicrobial against the isolated MRSA did not improve the ocular lesion. The MRSA strain was found to be staphylococcal cassette chromosome mec type II, a strain frequently isolated from humans in Japan.
publisher	The Japanese Society of Equine Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591416/
_version_	1613482932931919872

Methicillin-resistant Staphylococcus aureus ulcerative keratitis in a Thoroughbred racehorse

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