Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity
The HOPS tethering complex facilitates autophagosome-lysosome fusion by binding to Syx17 (Syntaxin 17), the autophagosomal SNARE. Here we show that loss of the core HOPS complex subunit Vps16A enhances autophagosome formation and slows down Drosophila development. Mechanistically, Tor kinase is less...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Taylor & Francis
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590676/ |