Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats

Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA), a natural compound extracted from a traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit lung injury and...

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Main Authors:	Gao, Lili, Tang, Haiying, He, Huanyu, Liu, Jia, Mao, Jingwei, Ji, Hong, Lin, Hongli, Wu, Taihua
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589765/

id	pubmed-4589765
recordtype	oai_dc
spelling	pubmed-45897652015-10-19 Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats Gao, Lili Tang, Haiying He, Huanyu Liu, Jia Mao, Jingwei Ji, Hong Lin, Hongli Wu, Taihua Pharmacology Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA), a natural compound extracted from a traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit lung injury and liver fibrosis in animal models, yet whether GA has a therapeutic effect on pulmonary fibrosis is unknown. In this study, we investigated the potential therapeutic effect of GA on pulmonary fibrosis in a rat model with bleomycin (BLM)-induced pulmonary fibrosis. The results indicated that GA treatment remarkably ameliorated BLM-induced pulmonary fibrosis and attenuated BLM-induced inflammation, oxidative stress, epithelial-mesenchymal transition, and activation of transforming growth factor-beta signaling pathway in the lungs. Further, we demonstrated that GA treatment inhibited proliferation of 3T6 fibroblast cells, induced cell cycle arrest and promoted apoptosis in vitro, implying that GA-mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. In summary, our study suggests a therapeutic potential of GA in the treatment of pulmonary fibrosis. Frontiers Media S.A. 2015-10-01 /pmc/articles/PMC4589765/ /pubmed/26483688 http://dx.doi.org/10.3389/fphar.2015.00215 Text en Copyright © 2015 Gao, Tang, He, Liu, Mao, Ji, Lin and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Gao, Lili Tang, Haiying He, Huanyu Liu, Jia Mao, Jingwei Ji, Hong Lin, Hongli Wu, Taihua
spellingShingle	Gao, Lili Tang, Haiying He, Huanyu Liu, Jia Mao, Jingwei Ji, Hong Lin, Hongli Wu, Taihua Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats
author_facet	Gao, Lili Tang, Haiying He, Huanyu Liu, Jia Mao, Jingwei Ji, Hong Lin, Hongli Wu, Taihua
author_sort	Gao, Lili
title	Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats
title_short	Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats
title_full	Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats
title_fullStr	Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats
title_full_unstemmed	Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats
title_sort	glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats
description	Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA), a natural compound extracted from a traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit lung injury and liver fibrosis in animal models, yet whether GA has a therapeutic effect on pulmonary fibrosis is unknown. In this study, we investigated the potential therapeutic effect of GA on pulmonary fibrosis in a rat model with bleomycin (BLM)-induced pulmonary fibrosis. The results indicated that GA treatment remarkably ameliorated BLM-induced pulmonary fibrosis and attenuated BLM-induced inflammation, oxidative stress, epithelial-mesenchymal transition, and activation of transforming growth factor-beta signaling pathway in the lungs. Further, we demonstrated that GA treatment inhibited proliferation of 3T6 fibroblast cells, induced cell cycle arrest and promoted apoptosis in vitro, implying that GA-mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. In summary, our study suggests a therapeutic potential of GA in the treatment of pulmonary fibrosis.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589765/
_version_	1613482382034206720

Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats

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