Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children

Background: Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism.

Bibliographic Details
Main Authors: Sharp, Gemma C, Lawlor, Debbie A, Richmond, Rebecca C, Fraser, Abigail, Simpkin, Andrew, Suderman, Matthew, Shihab, Hashem A, Lyttleton, Oliver, McArdle, Wendy, Ring, Susan M, Gaunt, Tom R, Davey Smith, George, Relton, Caroline L
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588865/
Description
Summary:Background: Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism.