Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons

Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons

•GAL-LepRbKO shows ↓ galanin and ↓ GalR1 mRNA, ↑ body weight gain.•GAL-LepRbKO shows ↑ orexin/hypocretin neuronal activation.•GAL-LepRb neurons innervate local orexin/hypocretin and noradrenergic locus coeruleus neurons.•Leptin regulates natural reward and body weight via GAL-LepRb neurons....

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Bibliographic Details
Main Authors: Laque, Amanda, Yu, Sangho, Qualls-Creekmore, Emily, Gettys, Sarah, Schwartzenburg, Candice, Bui, Kelly, Rhodes, Christopher, Berthoud, Hans-Rudolf, Morrison, Christopher D., Richards, Brenda K., Münzberg, Heike
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588437/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588437/

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