Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke

The use and effectiveness of current stroke reperfusion therapies are limited by the complications of reperfusion injury, which include increased cerebrovascular permeability and haemorrhagic transformation. Sphingosine-1-phosphate (S1P) is emerging as a potent modulator of vascular integrity via it...

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Bibliographic Details
Main Authors: Kim, Gab Seok, Yang, Li, Zhang, Guoqi, Zhao, Honggang, Selim, Magdy, McCullough, Louise D., Kluk, Michael J., Sanchez, Teresa
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587559/