Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review
Movement of tumours, mostly by respiration, has been a major problem for treating lung cancer, liver tumours and other locations in the abdomen and thorax. Organ motion is indeed one component of geometrical uncertainties that includes delineation and target definition uncertainties, microscopic dis...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
MDPI
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586762/ |
| id |
pubmed-4586762 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-45867622015-10-06 Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review De Ruysscher, Dirk Sterpin, Edmond Haustermans, Karin Depuydt, Tom Review Movement of tumours, mostly by respiration, has been a major problem for treating lung cancer, liver tumours and other locations in the abdomen and thorax. Organ motion is indeed one component of geometrical uncertainties that includes delineation and target definition uncertainties, microscopic disease and setup errors. At present, minimising motion seems to be the easiest to implement in clinical practice. If combined with adaptive approaches to correct for gradual anatomical variations, it may be a practical strategy. Other approaches such as repainting and tracking could increase the accuracy of proton therapy delivery, but advanced 4D solutions are needed. Moreover, there is a need to perform clinical studies to investigate which approach is the best in a given clinical situation. The good news is that existing and emerging technology and treatment planning systems as will without doubt lead in the forthcoming future to practical solutions to tackle intra-fraction motion in proton therapy. These developments may also improve motion management in photon therapy as well. MDPI 2015-06-29 /pmc/articles/PMC4586762/ /pubmed/26132317 http://dx.doi.org/10.3390/cancers7030829 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
De Ruysscher, Dirk Sterpin, Edmond Haustermans, Karin Depuydt, Tom |
| spellingShingle |
De Ruysscher, Dirk Sterpin, Edmond Haustermans, Karin Depuydt, Tom Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review |
| author_facet |
De Ruysscher, Dirk Sterpin, Edmond Haustermans, Karin Depuydt, Tom |
| author_sort |
De Ruysscher, Dirk |
| title |
Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review |
| title_short |
Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review |
| title_full |
Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review |
| title_fullStr |
Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review |
| title_full_unstemmed |
Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review |
| title_sort |
tumour movement in proton therapy: solutions and remaining questions: a review |
| description |
Movement of tumours, mostly by respiration, has been a major problem for treating lung cancer, liver tumours and other locations in the abdomen and thorax. Organ motion is indeed one component of geometrical uncertainties that includes delineation and target definition uncertainties, microscopic disease and setup errors. At present, minimising motion seems to be the easiest to implement in clinical practice. If combined with adaptive approaches to correct for gradual anatomical variations, it may be a practical strategy. Other approaches such as repainting and tracking could increase the accuracy of proton therapy delivery, but advanced 4D solutions are needed. Moreover, there is a need to perform clinical studies to investigate which approach is the best in a given clinical situation. The good news is that existing and emerging technology and treatment planning systems as will without doubt lead in the forthcoming future to practical solutions to tackle intra-fraction motion in proton therapy. These developments may also improve motion management in photon therapy as well. |
| publisher |
MDPI |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586762/ |
| _version_ |
1613481363254542336 |