Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response

Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response

During peripheral arterial disease, MSX1 acts downstream of BMP–SMAD signaling to transduce the arterial shear stimulus into an arteriogenic remodeling response. MSX1 activates collateral endothelium into a proinflammatory state through ICAM1/VCAM1 up-regulation, resulting in increased leukocyte inf...

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Bibliographic Details
Main Authors: Vandersmissen, Ine, Craps, Sander, Depypere, Maarten, Coppiello, Giulia, van Gastel, Nick, Maes, Frederik, Carmeliet, Geert, Schrooten, Jan, Jones, Elizabeth A.V., Umans, Lieve, Devlieger, Roland, Koole, Michel, Gheysens, Olivier, Zwijsen, An, Aranguren, Xabier L., Luttun, Aernout
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586738/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586738/

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