Regulatory T Cells Modulate DNA Vaccine Immunogenicity at Early Time via Functional CD4+ T Cells and Antigen Duration
The development of an effective vaccine against HIV has proved to be difficult. Many factors including natural regulatory T cells (Treg cells) can dampen the CD8 T-cell immunogenicity. In this study, we aimed to understand how Treg cells control CD8+ T-cell immune responses during DNA prime-boost im...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586510/ |