Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females

Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females

In this study we applied a new analytical strategy to investigate the relations between stochastic epigenetic mutations (SEMs) and aging. We analysed methylation levels through the Infinium HumanMethylation27 and HumanMethylation450 BeadChips in a population of 178 subjects ranging from 3 to 106 yea...

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Bibliographic Details
Main Authors: Gentilini, Davide, Garagnani, Paolo, Pisoni, Serena, Bacalini, Maria Giulia, Calzari, Luciano, Mari, Daniela, Vitale, Giovanni, Franceschi, Claudio, Di Blasio, Anna Maria
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586102/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586102/

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