Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making

We demonstrate an analog type logical device that combines metalloprotein and organic/inorganic materials and can make an interactive analog decision. Myoglobin is used as a functional biomolecule to generate electrochemical signals, and its original redox signal is controlled with various mercapto-...

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Main Authors:	Chung, Yong-Ho, Lee, Taek, Yoo, Si-Youl, Min, Junhong, Choi, Jeong-Woo
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585857/

id	pubmed-4585857
recordtype	oai_dc
spelling	pubmed-45858572015-09-30 Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making Chung, Yong-Ho Lee, Taek Yoo, Si-Youl Min, Junhong Choi, Jeong-Woo Article We demonstrate an analog type logical device that combines metalloprotein and organic/inorganic materials and can make an interactive analog decision. Myoglobin is used as a functional biomolecule to generate electrochemical signals, and its original redox signal is controlled with various mercapto-acids by the distance effect between myoglobin and a metal surface in the process of electron transfer. Controlled signals are modulated with the introduction of inorganic materials including nanoparticles and metal ions. By forming a hybrid structure with various constituents of organic/inorganic materials, several functions for signal manipulation were achieved, including enhancement, suppression, and shift. Based on the manipulated signals of biomolecules, a novel logical system for interactive decision-making processes is proposed by selectively combining different signals. Through the arrangement of various output signals, we can define interactive logical results regulated by an inherent tendency (by metalloprotein), personal experience (by organic spacer sets), and environments (by inorganic materials). As a practical application, a group decision process is presented using the proposed logical device. The proposed flexible logic process could facilitate the realization of an artificial intelligence system by mimicking the sophisticated human logic process. Nature Publishing Group 2015-09-24 /pmc/articles/PMC4585857/ /pubmed/26400018 http://dx.doi.org/10.1038/srep14501 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chung, Yong-Ho Lee, Taek Yoo, Si-Youl Min, Junhong Choi, Jeong-Woo
spellingShingle	Chung, Yong-Ho Lee, Taek Yoo, Si-Youl Min, Junhong Choi, Jeong-Woo Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making
author_facet	Chung, Yong-Ho Lee, Taek Yoo, Si-Youl Min, Junhong Choi, Jeong-Woo
author_sort	Chung, Yong-Ho
title	Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making
title_short	Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making
title_full	Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making
title_fullStr	Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making
title_full_unstemmed	Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making
title_sort	electrochemical bioelectronic device consisting of metalloprotein for analog decision making
description	We demonstrate an analog type logical device that combines metalloprotein and organic/inorganic materials and can make an interactive analog decision. Myoglobin is used as a functional biomolecule to generate electrochemical signals, and its original redox signal is controlled with various mercapto-acids by the distance effect between myoglobin and a metal surface in the process of electron transfer. Controlled signals are modulated with the introduction of inorganic materials including nanoparticles and metal ions. By forming a hybrid structure with various constituents of organic/inorganic materials, several functions for signal manipulation were achieved, including enhancement, suppression, and shift. Based on the manipulated signals of biomolecules, a novel logical system for interactive decision-making processes is proposed by selectively combining different signals. Through the arrangement of various output signals, we can define interactive logical results regulated by an inherent tendency (by metalloprotein), personal experience (by organic spacer sets), and environments (by inorganic materials). As a practical application, a group decision process is presented using the proposed logical device. The proposed flexible logic process could facilitate the realization of an artificial intelligence system by mimicking the sophisticated human logic process.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585857/
_version_	1613481035068080128

Electrochemical Bioelectronic Device Consisting of Metalloprotein for Analog Decision Making

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