From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting

Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another...

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Main Authors:	Boeger, Hinrich, Shelansky, Robert, Patel, Heta, Brown, Christopher R.
Format:	Online
Language:	English
Published:	MDPI 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584311/

id	pubmed-4584311
recordtype	oai_dc
spelling	pubmed-45843112015-10-05 From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting Boeger, Hinrich Shelansky, Robert Patel, Heta Brown, Christopher R. Review Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from “closed” to “open” chromatin. In contradistinction to this static and deterministic view of the problem, a dynamical and probabilistic theory of promoter chromatin has emerged as its solution. This theory, which we review here, explains observed variation in promoter chromatin structure at the level of single gene molecules and provides a molecular basis for random bursting in transcription—the conjecture that promoters stochastically transition between transcriptionally conducive and inconducive states. The mechanism of transcriptional regulation may be understood only in probabilistic terms. MDPI 2015-06-30 /pmc/articles/PMC4584311/ /pubmed/26136240 http://dx.doi.org/10.3390/genes6030469 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Boeger, Hinrich Shelansky, Robert Patel, Heta Brown, Christopher R.
spellingShingle	Boeger, Hinrich Shelansky, Robert Patel, Heta Brown, Christopher R. From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting
author_facet	Boeger, Hinrich Shelansky, Robert Patel, Heta Brown, Christopher R.
author_sort	Boeger, Hinrich
title	From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting
title_short	From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting
title_full	From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting
title_fullStr	From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting
title_full_unstemmed	From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting
title_sort	from structural variation of gene molecules to chromatin dynamics and transcriptional bursting
description	Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from “closed” to “open” chromatin. In contradistinction to this static and deterministic view of the problem, a dynamical and probabilistic theory of promoter chromatin has emerged as its solution. This theory, which we review here, explains observed variation in promoter chromatin structure at the level of single gene molecules and provides a molecular basis for random bursting in transcription—the conjecture that promoters stochastically transition between transcriptionally conducive and inconducive states. The mechanism of transcriptional regulation may be understood only in probabilistic terms.
publisher	MDPI
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584311/
_version_	1613480252860792832

From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting

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