Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering
We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by...
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| Format: | Online |
| Language: | English |
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MDPI
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584290/ |
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pubmed-4584290 |
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pubmed-45842902015-10-05 Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering Kučerka, Norbert Heberle, Frederick A. Pan, Jianjun Katsaras, John Review We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). From model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.). MDPI 2015-09-21 /pmc/articles/PMC4584290/ /pubmed/26402708 http://dx.doi.org/10.3390/membranes5030454 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kučerka, Norbert Heberle, Frederick A. Pan, Jianjun Katsaras, John |
| spellingShingle |
Kučerka, Norbert Heberle, Frederick A. Pan, Jianjun Katsaras, John Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| author_facet |
Kučerka, Norbert Heberle, Frederick A. Pan, Jianjun Katsaras, John |
| author_sort |
Kučerka, Norbert |
| title |
Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_short |
Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_full |
Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_fullStr |
Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_full_unstemmed |
Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering |
| title_sort |
structural significance of lipid diversity as studied by small angle neutron and x-ray scattering |
| description |
We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). From model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.). |
| publisher |
MDPI |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584290/ |
| _version_ |
1613480241588600832 |