Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have d...
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Hindawi Publishing Corporation
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584050/ |
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pubmed-45840502015-10-07 Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms Yap, Ning Yi Rajandram, Retnagowri Ng, Keng Lim Pailoor, Jayalakshmi Fadzli, Ahmad Gobe, Glenda Carolyn Review Article The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed. Hindawi Publishing Corporation 2015 2015-09-13 /pmc/articles/PMC4584050/ /pubmed/26448938 http://dx.doi.org/10.1155/2015/476508 Text en Copyright © 2015 Ning Yi Yap et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yap, Ning Yi Rajandram, Retnagowri Ng, Keng Lim Pailoor, Jayalakshmi Fadzli, Ahmad Gobe, Glenda Carolyn |
| spellingShingle |
Yap, Ning Yi Rajandram, Retnagowri Ng, Keng Lim Pailoor, Jayalakshmi Fadzli, Ahmad Gobe, Glenda Carolyn Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms |
| author_facet |
Yap, Ning Yi Rajandram, Retnagowri Ng, Keng Lim Pailoor, Jayalakshmi Fadzli, Ahmad Gobe, Glenda Carolyn |
| author_sort |
Yap, Ning Yi |
| title |
Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms |
| title_short |
Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms |
| title_full |
Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms |
| title_fullStr |
Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms |
| title_full_unstemmed |
Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms |
| title_sort |
genetic and chromosomal aberrations and their clinical significance in renal neoplasms |
| description |
The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584050/ |
| _version_ |
1613480156603613184 |