The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

Aberrant activation of oncogenic kinases is frequently observed in human cancers, but the underlying mechanism and resulting effects on global signaling are incompletely understood. Here, we demonstrate that the oncogenic FIP1L1-PDGFRα kinase exhibits a significantly different signaling pattern comp...

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Bibliographic Details
Main Authors: Haan, Serge, Bahlawane, Christelle, Wang, Jiali, Nazarov, Petr V, Muller, Arnaud, Eulenfeld, René, Haan, Claude, Rolvering, Catherine, Vallar, Laurent, Satagopam, Venkata P, Sauter, Thomas, Wiesinger, Monique Yvonne
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583054/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583054/

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