VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 suppressed DJM-1 cell proliferation. Furthermore, the overexpression of the NRP1 wild type restored s...

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Bibliographic Details
Main Authors: Yoshida, Ayumi, Shimizu, Akio, Asano, Hirotsugu, Kadonosono, Tetsuya, Kondoh, Shinae Kizaka, Geretti, Elena, Mammoto, Akiko, Klagsbrun, Michael, Seo, Misuzu Kurokawa
Format: Online
Language:English
Published: The Company of Biologists 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582117/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582117/

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