Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
Anti-angiogenic treatments against αvβ3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation o...
| Main Authors: | , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582102/ |