Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

Immunoglobulins M (IgMs) are gaining increasing attention as biopharmaceuticals since their multivalent mode of binding can give rise to high avidity. Furthermore, IgMs are potent activators of the complement system. However, they are frequently difficult to express recombinantly and can suffer from...

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Bibliographic Details
Main Authors: Chromikova, Veronika, Mader, Alexander, Hofbauer, Stefan, Göbl, Christoph, Madl, Tobias, Gach, Johannes S., Bauernfried, Stefan, Furtmüller, Paul G., Forthal, Donald N., Mach, Lukas, Obinger, Christian, Kunert, Renate
Format: Online
Language:English
Published: Elsevier Pub. Co 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582045/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582045/

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