Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discove...

Full description

Bibliographic Details
Main Authors:	Herraiz, Ignacio, Simón, Elisa, Gómez-Arriaga, Paula Isabel, Martínez-Moratalla, José Manuel, García-Burguillo, Antonio, López Jiménez, Elena Ana, Galindo, Alberto
Format:	Online
Language:	English
Published:	MDPI 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581283/

id	pubmed-4581283
recordtype	oai_dc
spelling	pubmed-45812832015-09-28 Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration Herraiz, Ignacio Simón, Elisa Gómez-Arriaga, Paula Isabel Martínez-Moratalla, José Manuel García-Burguillo, Antonio López Jiménez, Elena Ana Galindo, Alberto Review Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of sFlt-1/PlGF and propose a new protocol for its clinical integration. MDPI 2015-08-13 /pmc/articles/PMC4581283/ /pubmed/26287164 http://dx.doi.org/10.3390/ijms160819009 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Herraiz, Ignacio Simón, Elisa Gómez-Arriaga, Paula Isabel Martínez-Moratalla, José Manuel García-Burguillo, Antonio López Jiménez, Elena Ana Galindo, Alberto
spellingShingle	Herraiz, Ignacio Simón, Elisa Gómez-Arriaga, Paula Isabel Martínez-Moratalla, José Manuel García-Burguillo, Antonio López Jiménez, Elena Ana Galindo, Alberto Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration
author_facet	Herraiz, Ignacio Simón, Elisa Gómez-Arriaga, Paula Isabel Martínez-Moratalla, José Manuel García-Burguillo, Antonio López Jiménez, Elena Ana Galindo, Alberto
author_sort	Herraiz, Ignacio
title	Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration
title_short	Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration
title_full	Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration
title_fullStr	Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration
title_full_unstemmed	Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration
title_sort	angiogenesis-related biomarkers (sflt-1/plgf) in the prediction and diagnosis of placental dysfunction: an approach for clinical integration
description	Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of sFlt-1/PlGF and propose a new protocol for its clinical integration.
publisher	MDPI
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581283/
_version_	1613479203250896896

Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

Similar Items