Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936
Epidemiological studies have reported inverse associations between various single healthy diet indices and lower levels of systemic inflammation, but rarely are they examined in the same sample. The aim of the present study was to investigate the potential relationships between biomarkers of systemi...
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| Format: | Online |
| Language: | English |
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Cambridge University Press
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579562/ |
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pubmed-45795622015-09-24 Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936 Corley, Janie Kyle, Janet A. M. Starr, John M. McNeill, Geraldine Deary, Ian J. Full Papers Epidemiological studies have reported inverse associations between various single healthy diet indices and lower levels of systemic inflammation, but rarely are they examined in the same sample. The aim of the present study was to investigate the potential relationships between biomarkers of systemic inflammation (C-reactive protein (CRP) and fibrinogen) and overall foods (dietary patterns), single foods (fruits and vegetables), and specific nutritive (antioxidants) and non-nutritive (flavonoids) food components in the same narrow-age cohort of older adults. The dietary intake of 792 participants aged 70 years from the Lothian Birth Cohort 1936 was assessed using a 168-item FFQ. Models were adjusted for age, sex, childhood cognitive ability, lifestyle factors and history of disease. Using logistic regression analyses, CRP (normal v. elevated) was favourably associated (at P< 0·05) with the ‘health-aware’ (low-fat) dietary pattern (unstandardised β = (0·200, OR 0·82, 95 % CI 0·68, 0·99) and fruit intake (unstandardised β = (0·100, OR 0·91, 95 % CI 0·82, 0·99), including flavonoid-rich apples (unstandardised β = (0·456, OR 0·63, 95 % CI 0·439, 0·946). Using linear regression analyses, fibrinogen (continuous) was inversely associated (at P< 0·05) with the Mediterranean dietary pattern (standardised β = (0·100), fruit intake (standardised β = (0·083), and combined fruit and vegetable intake (standardised β = (0·084). We observed no association between food components (antioxidant nutrients or specific flavonoid subclasses) and inflammatory markers. In the present cross-sectional study, nutrient-dense dietary patterns were associated with lower levels of systemic inflammation in older people. The results are consistent with dietary guidelines that promote a balanced diet based on a variety of plant-based foods. Cambridge University Press 2015-10-14 2015-09-07 /pmc/articles/PMC4579562/ /pubmed/26343358 http://dx.doi.org/10.1017/S000711451500210X Text en © The Authors 2015 http://creativecommons.org/licenses/by/3.0/ The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution license http://creativecommons.org/licenses/by/3.0/. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Corley, Janie Kyle, Janet A. M. Starr, John M. McNeill, Geraldine Deary, Ian J. |
| spellingShingle |
Corley, Janie Kyle, Janet A. M. Starr, John M. McNeill, Geraldine Deary, Ian J. Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936 |
| author_facet |
Corley, Janie Kyle, Janet A. M. Starr, John M. McNeill, Geraldine Deary, Ian J. |
| author_sort |
Corley, Janie |
| title |
Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936 |
| title_short |
Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936 |
| title_full |
Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936 |
| title_fullStr |
Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936 |
| title_full_unstemmed |
Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936 |
| title_sort |
dietary factors and biomarkers of systemic inflammation in older people: the lothian birth cohort 1936 |
| description |
Epidemiological studies have reported inverse associations between various single healthy diet indices and lower levels of systemic inflammation, but rarely are they examined in the same sample. The aim of the present study was to investigate the potential relationships between biomarkers of systemic inflammation (C-reactive protein (CRP) and fibrinogen) and overall foods (dietary patterns), single foods (fruits and vegetables), and specific nutritive (antioxidants) and non-nutritive (flavonoids) food components in the same narrow-age cohort of older adults. The dietary intake of 792 participants aged 70 years from the Lothian Birth Cohort 1936 was assessed using a 168-item FFQ. Models were adjusted for age, sex, childhood cognitive ability, lifestyle factors and history of disease. Using logistic regression analyses, CRP (normal v. elevated) was favourably associated (at P< 0·05) with the ‘health-aware’ (low-fat) dietary pattern (unstandardised β = (0·200, OR 0·82, 95 % CI 0·68, 0·99) and fruit intake (unstandardised β = (0·100, OR 0·91, 95 % CI 0·82, 0·99), including flavonoid-rich apples (unstandardised β = (0·456, OR 0·63, 95 % CI 0·439, 0·946). Using linear regression analyses, fibrinogen (continuous) was inversely associated (at P< 0·05) with the Mediterranean dietary pattern (standardised β = (0·100), fruit intake (standardised β = (0·083), and combined fruit and vegetable intake (standardised β = (0·084). We observed no association between food components (antioxidant nutrients or specific flavonoid subclasses) and inflammatory markers. In the present cross-sectional study, nutrient-dense dietary patterns were associated with lower levels of systemic inflammation in older people. The results are consistent with dietary guidelines that promote a balanced diet based on a variety of plant-based foods. |
| publisher |
Cambridge University Press |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579562/ |
| _version_ |
1613478574227980288 |