Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit

The last two decades have seen a strong rise in empirical research in the mechanisms of emotion dysregulation in borderline personality disorder. Major findings comprise structural as well as functional alterations of brain regions involved in emotion processing, such as amygdala, insula, and prefro...

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Main Authors:	Schmahl, Christian, Herpertz, Sabine C, Bertsch, Katja, Ende, Gabriele, Flor, Herta, Kirsch, Peter, Lis, Stefanie, Meyer-Lindenberg, Andreas, Rietschel, Marcella, Schneider, Miriam, Spanagel, Rainer, Treede, Rolf-Detlef, Bohus, Martin
Format:	Online
Language:	English
Published:	BioMed Central 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579501/

id	pubmed-4579501
recordtype	oai_dc
spelling	pubmed-45795012015-09-23 Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit Schmahl, Christian Herpertz, Sabine C Bertsch, Katja Ende, Gabriele Flor, Herta Kirsch, Peter Lis, Stefanie Meyer-Lindenberg, Andreas Rietschel, Marcella Schneider, Miriam Spanagel, Rainer Treede, Rolf-Detlef Bohus, Martin Review The last two decades have seen a strong rise in empirical research in the mechanisms of emotion dysregulation in borderline personality disorder. Major findings comprise structural as well as functional alterations of brain regions involved in emotion processing, such as amygdala, insula, and prefrontal regions. In addition, more specific mechanisms of disturbed emotion regulation, e.g. related to pain and dissociation, have been identified. Most recently, social interaction problems and their underlying neurobiological mechanisms, e.g. disturbed trust or hypersensitivity to social rejection, have become a major focus of BPD research. This article covers the current state of knowledge and related relevant research goals. The first part presents a review of the literature. The second part delineates important open questions to be addressed in future studies. The third part describes the research agenda for a large German center grant focusing on mechanisms of emotion dysregulation in BPD. BioMed Central 2014-09-09 /pmc/articles/PMC4579501/ /pubmed/26401296 http://dx.doi.org/10.1186/2051-6673-1-12 Text en © Schmahl et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Schmahl, Christian Herpertz, Sabine C Bertsch, Katja Ende, Gabriele Flor, Herta Kirsch, Peter Lis, Stefanie Meyer-Lindenberg, Andreas Rietschel, Marcella Schneider, Miriam Spanagel, Rainer Treede, Rolf-Detlef Bohus, Martin
spellingShingle	Schmahl, Christian Herpertz, Sabine C Bertsch, Katja Ende, Gabriele Flor, Herta Kirsch, Peter Lis, Stefanie Meyer-Lindenberg, Andreas Rietschel, Marcella Schneider, Miriam Spanagel, Rainer Treede, Rolf-Detlef Bohus, Martin Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit
author_facet	Schmahl, Christian Herpertz, Sabine C Bertsch, Katja Ende, Gabriele Flor, Herta Kirsch, Peter Lis, Stefanie Meyer-Lindenberg, Andreas Rietschel, Marcella Schneider, Miriam Spanagel, Rainer Treede, Rolf-Detlef Bohus, Martin
author_sort	Schmahl, Christian
title	Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit
title_short	Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit
title_full	Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit
title_fullStr	Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit
title_full_unstemmed	Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit
title_sort	mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the german clinical research unit
description	The last two decades have seen a strong rise in empirical research in the mechanisms of emotion dysregulation in borderline personality disorder. Major findings comprise structural as well as functional alterations of brain regions involved in emotion processing, such as amygdala, insula, and prefrontal regions. In addition, more specific mechanisms of disturbed emotion regulation, e.g. related to pain and dissociation, have been identified. Most recently, social interaction problems and their underlying neurobiological mechanisms, e.g. disturbed trust or hypersensitivity to social rejection, have become a major focus of BPD research. This article covers the current state of knowledge and related relevant research goals. The first part presents a review of the literature. The second part delineates important open questions to be addressed in future studies. The third part describes the research agenda for a large German center grant focusing on mechanisms of emotion dysregulation in BPD.
publisher	BioMed Central
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579501/
_version_	1613478556926476288

Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit

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