Sliding tethered ligands add topological interactions to the toolbox of ligand–receptor design

Adhesion in the biological realm is mediated by specific lock-and-key interactions between ligand–receptor pairs. These complementary moieties are ubiquitously anchored to substrates by tethers that control the interaction range and the mobility of the ligands and receptors, thus tuning the kinetics...

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Bibliographic Details
Main Authors: Bauer, Martin, Kékicheff, Patrick, Iss, Jean, Fajolles, Christophe, Charitat, Thierry, Daillant, Jean, Marques, Carlos M.
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579401/