Central neural circuitry mediating courtship song perception in male Drosophila

Animals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. I...

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Main Authors:	Zhou, Chuan, Franconville, Romain, Vaughan, Alexander G, Robinett, Carmen C, Jayaraman, Vivek, Baker, Bruce S
Format:	Online
Language:	English
Published:	eLife Sciences Publications, Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575990/

id	pubmed-4575990
recordtype	oai_dc
spelling	pubmed-45759902015-09-22 Central neural circuitry mediating courtship song perception in male Drosophila Zhou, Chuan Franconville, Romain Vaughan, Alexander G Robinett, Carmen C Jayaraman, Vivek Baker, Bruce S Neuroscience Animals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. In this study, we identified a male-specific pathway for courtship hearing via third-order ventrolateral protocerebrum Projection Neuron 1 (vPN1) neurons and fourth-order pC1 neurons. Genetic inactivation of vPN1 or pC1 disrupts song-induced male-chaining behavior. Calcium imaging reveals that vPN1 responds preferentially to pulse song with long inter-pulse intervals (IPIs), while pC1 responses to pulse song closely match the behavioral chaining responses at different IPIs. Moreover, genetic activation of either vPN1 or pC1 induced courtship chaining, mimicking the behavioral response to song. These results outline the aPN1-vPN1-pC1 pathway as a labeled line for the processing and transformation of courtship song in males. eLife Sciences Publications, Ltd 2015-09-21 /pmc/articles/PMC4575990/ /pubmed/26390382 http://dx.doi.org/10.7554/eLife.08477 Text en © 2015, Zhou et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Zhou, Chuan Franconville, Romain Vaughan, Alexander G Robinett, Carmen C Jayaraman, Vivek Baker, Bruce S
spellingShingle	Zhou, Chuan Franconville, Romain Vaughan, Alexander G Robinett, Carmen C Jayaraman, Vivek Baker, Bruce S Central neural circuitry mediating courtship song perception in male Drosophila
author_facet	Zhou, Chuan Franconville, Romain Vaughan, Alexander G Robinett, Carmen C Jayaraman, Vivek Baker, Bruce S
author_sort	Zhou, Chuan
title	Central neural circuitry mediating courtship song perception in male Drosophila
title_short	Central neural circuitry mediating courtship song perception in male Drosophila
title_full	Central neural circuitry mediating courtship song perception in male Drosophila
title_fullStr	Central neural circuitry mediating courtship song perception in male Drosophila
title_full_unstemmed	Central neural circuitry mediating courtship song perception in male Drosophila
title_sort	central neural circuitry mediating courtship song perception in male drosophila
description	Animals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. In this study, we identified a male-specific pathway for courtship hearing via third-order ventrolateral protocerebrum Projection Neuron 1 (vPN1) neurons and fourth-order pC1 neurons. Genetic inactivation of vPN1 or pC1 disrupts song-induced male-chaining behavior. Calcium imaging reveals that vPN1 responds preferentially to pulse song with long inter-pulse intervals (IPIs), while pC1 responses to pulse song closely match the behavioral chaining responses at different IPIs. Moreover, genetic activation of either vPN1 or pC1 induced courtship chaining, mimicking the behavioral response to song. These results outline the aPN1-vPN1-pC1 pathway as a labeled line for the processing and transformation of courtship song in males.
publisher	eLife Sciences Publications, Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575990/
_version_	1613477548209995776

Central neural circuitry mediating courtship song perception in male Drosophila

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