The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease

The prognostic role of resting pulmonary hyperinflation as measured by residual volume (RV)/total lung capacity (TLC) in chronic obstructive pulmonary disease (COPD) remains poorly understood. Therefore, this study aimed to identify the factors related to resting pulmonary hyperinflation in COPD and...

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Main Authors:	Shin, Tae Rim, Oh, Yeon-Mok, Park, Joo Hun, Lee, Keu Sung, Oh, Sunghee, Kang, Dae Ryoung, Sheen, Seungsoo, Seo, Joon Beom, Yoo, Kwang Ha, Lee, Ji-Hyun, Kim, Tae-Hyung, Lim, Seong Yong, Yoon, Ho Il, Rhee, Chin Kook, Choe, Kang-Hyeon, Lee, Jae Seung, Lee, Sang-Do
Format:	Online
Language:	English
Published:	The Korean Academy of Medical Sciences 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575935/

id	pubmed-4575935
recordtype	oai_dc
spelling	pubmed-45759352015-10-01 The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease Shin, Tae Rim Oh, Yeon-Mok Park, Joo Hun Lee, Keu Sung Oh, Sunghee Kang, Dae Ryoung Sheen, Seungsoo Seo, Joon Beom Yoo, Kwang Ha Lee, Ji-Hyun Kim, Tae-Hyung Lim, Seong Yong Yoon, Ho Il Rhee, Chin Kook Choe, Kang-Hyeon Lee, Jae Seung Lee, Sang-Do Original Article The prognostic role of resting pulmonary hyperinflation as measured by residual volume (RV)/total lung capacity (TLC) in chronic obstructive pulmonary disease (COPD) remains poorly understood. Therefore, this study aimed to identify the factors related to resting pulmonary hyperinflation in COPD and to determine whether resting pulmonary hyperinflation is a prognostic factor in COPD. In total, 353 patients with COPD in the Korean Obstructive Lung Disease cohort recruited from 16 hospitals were enrolled. Resting pulmonary hyperinflation was defined as RV/TLC ≥ 40%. Multivariate logistic regression analysis demonstrated that older age (P = 0.001), lower forced expiratory volume in 1 second (FEV1) (P < 0.001), higher St. George Respiratory Questionnaire (SGRQ) score (P = 0.019), and higher emphysema index (P = 0.010) were associated independently with resting hyperinflation. Multivariate Cox regression model that included age, gender, dyspnea scale, SGRQ, RV/TLC, and 6-min walking distance revealed that an older age (HR = 1.07, P = 0.027), a higher RV/TLC (HR = 1.04, P = 0.025), and a shorter 6-min walking distance (HR = 0.99, P < 0.001) were independent predictors of all-cause mortality. Our data showed that older age, higher emphysema index, higher SGRQ score, and lower FEV1 were associated independently with resting pulmonary hyperinflation in COPD. RV/TLC is an independent risk factor for all-cause mortality in COPD. The Korean Academy of Medical Sciences 2015-10 2015-09-12 /pmc/articles/PMC4575935/ /pubmed/26425043 http://dx.doi.org/10.3346/jkms.2015.30.10.1459 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Shin, Tae Rim Oh, Yeon-Mok Park, Joo Hun Lee, Keu Sung Oh, Sunghee Kang, Dae Ryoung Sheen, Seungsoo Seo, Joon Beom Yoo, Kwang Ha Lee, Ji-Hyun Kim, Tae-Hyung Lim, Seong Yong Yoon, Ho Il Rhee, Chin Kook Choe, Kang-Hyeon Lee, Jae Seung Lee, Sang-Do
spellingShingle	Shin, Tae Rim Oh, Yeon-Mok Park, Joo Hun Lee, Keu Sung Oh, Sunghee Kang, Dae Ryoung Sheen, Seungsoo Seo, Joon Beom Yoo, Kwang Ha Lee, Ji-Hyun Kim, Tae-Hyung Lim, Seong Yong Yoon, Ho Il Rhee, Chin Kook Choe, Kang-Hyeon Lee, Jae Seung Lee, Sang-Do The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease
author_facet	Shin, Tae Rim Oh, Yeon-Mok Park, Joo Hun Lee, Keu Sung Oh, Sunghee Kang, Dae Ryoung Sheen, Seungsoo Seo, Joon Beom Yoo, Kwang Ha Lee, Ji-Hyun Kim, Tae-Hyung Lim, Seong Yong Yoon, Ho Il Rhee, Chin Kook Choe, Kang-Hyeon Lee, Jae Seung Lee, Sang-Do
author_sort	Shin, Tae Rim
title	The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease
title_short	The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease
title_full	The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease
title_fullStr	The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease
title_full_unstemmed	The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease
title_sort	prognostic value of residual volume/total lung capacity in patients with chronic obstructive pulmonary disease
description	The prognostic role of resting pulmonary hyperinflation as measured by residual volume (RV)/total lung capacity (TLC) in chronic obstructive pulmonary disease (COPD) remains poorly understood. Therefore, this study aimed to identify the factors related to resting pulmonary hyperinflation in COPD and to determine whether resting pulmonary hyperinflation is a prognostic factor in COPD. In total, 353 patients with COPD in the Korean Obstructive Lung Disease cohort recruited from 16 hospitals were enrolled. Resting pulmonary hyperinflation was defined as RV/TLC ≥ 40%. Multivariate logistic regression analysis demonstrated that older age (P = 0.001), lower forced expiratory volume in 1 second (FEV1) (P < 0.001), higher St. George Respiratory Questionnaire (SGRQ) score (P = 0.019), and higher emphysema index (P = 0.010) were associated independently with resting hyperinflation. Multivariate Cox regression model that included age, gender, dyspnea scale, SGRQ, RV/TLC, and 6-min walking distance revealed that an older age (HR = 1.07, P = 0.027), a higher RV/TLC (HR = 1.04, P = 0.025), and a shorter 6-min walking distance (HR = 0.99, P < 0.001) were independent predictors of all-cause mortality. Our data showed that older age, higher emphysema index, higher SGRQ score, and lower FEV1 were associated independently with resting pulmonary hyperinflation in COPD. RV/TLC is an independent risk factor for all-cause mortality in COPD.
publisher	The Korean Academy of Medical Sciences
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575935/
_version_	1613477523863109632

The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease

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