The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled

Mop regulates endosomal localization and recycling of Frizzled. Hrs is ubiquitinated and degraded in the absence of Mop. Mop aids in the maintenance of Ubpy to control the ubiquitin homeostasis of Hrs. Mop and Ubpy can rescue each other. Mop’s function is not required in the cell in the absence of t...

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Bibliographic Details
Main Authors: Pradhan-Sundd, Tirthadipa, Verheyen, Esther M.
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569321/