Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

Mitochondrial dysfunction and metabolic remodelling are pivotal in the development of cardiomyopathy. Here, we show that myocardial COUP-TFII overexpression causes heart failure in mice, suggesting a causal effect of elevated COUP-TFII levels on development of dilated cardiomyopathy. COUP-TFII repre...

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Bibliographic Details
Main Authors: Wu, San-Pin, Kao, Chung-Yang, Wang, Leiming, Creighton, Chad J., Yang, Jin, Donti, Taraka R., Harmancey, Romain, Vasquez, Hernan G., Graham, Brett H., Bellen, Hugo J., Taegtmeyer, Heinrich, Chang, Ching-Pin, Tsai, Ming-Jer, Tsai, Sophia Y.
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568566/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568566/

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