Blockade of CD82 by a monoclonal antibody potentiates anti-leukemia effects of AraC in vivo

We recently found that CD82 inhibits matrix metalloproteinase 9 and augments adhesion of CD34+/CD38− acute myelogenous leukemia (AML) cells to the bone marrow (BM) microenvironment. The present study found that the use of an anti-CD82 monoclonal antibody (CD82 mAb) mobilized CD34+ leukemia cells fro...

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Bibliographic Details
Main Authors: Nishioka, Chie, Ikezoe, Takayuki, Yokoyama, Akihito
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567027/