Rhein antagonizes P2X7 receptor in rat peritoneal macrophages

P2X7 receptor plays important roles in inflammation and immunity, and thereby it serves as a potential therapeutic target for inflammatory diseases. Rhein, an anthraquinone derivative, exhibits significant anti-inflammatory and immunosuppressive activities in therapy. However, the underlying mechani...

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Bibliographic Details
Main Authors: Hu, Fen, Xing, Fulin, Zhu, Ge, Xu, Guangxue, Li, Cunbo, Qu, Junle, Lee, Imshik, Pan, Leiting
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564849/