SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia

Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann's Area (BA) 9, and to determine the disease specifi...

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Main Authors:	Udawela, M, Money, T T, Neo, J, Seo, M S, Scarr, E, Dean, B, Everall, I P
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564563/

id	pubmed-4564563
recordtype	oai_dc
spelling	pubmed-45645632015-09-18 SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia Udawela, M Money, T T Neo, J Seo, M S Scarr, E Dean, B Everall, I P Original Article Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann's Area (BA) 9, and to determine the disease specificity of increased SELENBP1 expression by measuring SELENBP1 mRNA in subjects with major depressive disorder and bipolar disorder. We then extended the study to include other cortical regions such as BA8 and BA44. SELENBP1 mRNA was higher in BA9 (P=0.001), BA8 (P=0.003) and BA44 (P=0.0007) from subjects with schizophrenia. Conversely, in affective disorders, there was no significant difference in SELENBP1 mRNA in BA9 (P=0.67), suggesting that the upregulation may be diagnosis specific. Measurement of SELENBP1 protein levels showed that changes in mRNA did not translate to changes in protein. In addition, chronic treatment of rats with antipsychotics did not significantly affect the expression of Selenbp1 in the cortex (P=0.24). Our data show that elevated SELENBP1 transcript expression is widespread throughout the prefrontal cortex in schizophrenia, and confirm that this change is a consistent feature of schizophrenia and not a simple drug effect. Nature Publishing Group 2015-08 2015-08-04 /pmc/articles/PMC4564563/ /pubmed/26241353 http://dx.doi.org/10.1038/tp.2015.108 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Udawela, M Money, T T Neo, J Seo, M S Scarr, E Dean, B Everall, I P
spellingShingle	Udawela, M Money, T T Neo, J Seo, M S Scarr, E Dean, B Everall, I P SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
author_facet	Udawela, M Money, T T Neo, J Seo, M S Scarr, E Dean, B Everall, I P
author_sort	Udawela, M
title	SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
title_short	SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
title_full	SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
title_fullStr	SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
title_full_unstemmed	SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia
title_sort	selenbp1 expression in the prefrontal cortex of subjects with schizophrenia
description	Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann's Area (BA) 9, and to determine the disease specificity of increased SELENBP1 expression by measuring SELENBP1 mRNA in subjects with major depressive disorder and bipolar disorder. We then extended the study to include other cortical regions such as BA8 and BA44. SELENBP1 mRNA was higher in BA9 (P=0.001), BA8 (P=0.003) and BA44 (P=0.0007) from subjects with schizophrenia. Conversely, in affective disorders, there was no significant difference in SELENBP1 mRNA in BA9 (P=0.67), suggesting that the upregulation may be diagnosis specific. Measurement of SELENBP1 protein levels showed that changes in mRNA did not translate to changes in protein. In addition, chronic treatment of rats with antipsychotics did not significantly affect the expression of Selenbp1 in the cortex (P=0.24). Our data show that elevated SELENBP1 transcript expression is widespread throughout the prefrontal cortex in schizophrenia, and confirm that this change is a consistent feature of schizophrenia and not a simple drug effect.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564563/
_version_	1613474199935909888

SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia

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