Polymorphisms in Toll-like receptor genes are associated with vitiligo

Background: The members of Toll-like receptor (TLR) family are responsible for recognizing various molecular patterns associated with pathogens. Their expression is not confined to immune cells and have been detected in skin cells such as keratinocytes and melanocytes. As part of a generated respons...

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Main Authors:	Traks, Tanel, Keermann, Maris, Karelson, Maire, Rätsep, Ranno, Reimann, Ene, Silm, Helgi, Vasar, Eero, Kõks, Sulev, Kingo, Külli
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563240/

id	pubmed-4563240
recordtype	oai_dc
spelling	pubmed-45632402015-10-05 Polymorphisms in Toll-like receptor genes are associated with vitiligo Traks, Tanel Keermann, Maris Karelson, Maire Rätsep, Ranno Reimann, Ene Silm, Helgi Vasar, Eero Kõks, Sulev Kingo, Külli Pediatrics Background: The members of Toll-like receptor (TLR) family are responsible for recognizing various molecular patterns associated with pathogens. Their expression is not confined to immune cells and have been detected in skin cells such as keratinocytes and melanocytes. As part of a generated response to pathogens, TLRs are involved in inducing inflammatory mediators to combat these threats. It is therefore not surprising that TLRs have been implicated in inflammatory skin diseases, including atopic dermatitis and psoriasis. Likewise, as key players in autoimmunity, they have been associated with a number of autoimmune diseases. Based on this, the role of TLRs in vitiligo could be suspected, but is yet to be clearly established. Frontiers Media S.A. 2015-09-09 /pmc/articles/PMC4563240/ /pubmed/26442097 http://dx.doi.org/10.3389/fgene.2015.00278 Text en Copyright © 2015 Traks, Keermann, Karelson, Rätsep, Reimann, Silm, Vasar, Kõks and Kingo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Traks, Tanel Keermann, Maris Karelson, Maire Rätsep, Ranno Reimann, Ene Silm, Helgi Vasar, Eero Kõks, Sulev Kingo, Külli
spellingShingle	Traks, Tanel Keermann, Maris Karelson, Maire Rätsep, Ranno Reimann, Ene Silm, Helgi Vasar, Eero Kõks, Sulev Kingo, Külli Polymorphisms in Toll-like receptor genes are associated with vitiligo
author_facet	Traks, Tanel Keermann, Maris Karelson, Maire Rätsep, Ranno Reimann, Ene Silm, Helgi Vasar, Eero Kõks, Sulev Kingo, Külli
author_sort	Traks, Tanel
title	Polymorphisms in Toll-like receptor genes are associated with vitiligo
title_short	Polymorphisms in Toll-like receptor genes are associated with vitiligo
title_full	Polymorphisms in Toll-like receptor genes are associated with vitiligo
title_fullStr	Polymorphisms in Toll-like receptor genes are associated with vitiligo
title_full_unstemmed	Polymorphisms in Toll-like receptor genes are associated with vitiligo
title_sort	polymorphisms in toll-like receptor genes are associated with vitiligo
description	Background: The members of Toll-like receptor (TLR) family are responsible for recognizing various molecular patterns associated with pathogens. Their expression is not confined to immune cells and have been detected in skin cells such as keratinocytes and melanocytes. As part of a generated response to pathogens, TLRs are involved in inducing inflammatory mediators to combat these threats. It is therefore not surprising that TLRs have been implicated in inflammatory skin diseases, including atopic dermatitis and psoriasis. Likewise, as key players in autoimmunity, they have been associated with a number of autoimmune diseases. Based on this, the role of TLRs in vitiligo could be suspected, but is yet to be clearly established.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563240/
_version_	1613473781722906624

Polymorphisms in Toll-like receptor genes are associated with vitiligo

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