Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes

Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes

Autoimmune diseases are a group of chronic inflammatory diseases that arise from inappropriate inflammatory responses. Hinokitiol, isolated from the wood of Chamaecyparis taiwanensis, engages in multiple biological activities. Although hinokitiol has been reported to inhibit inflammation, its immuno...

Full description

Bibliographic Details
Main Authors:	Chung, Chi-Li, Leung, Kam-Wing, Lu, Wan-Jung, Yen, Ting-Lin, He, Chia-Fu, Sheu, Joen-Rong, Lin, Kuan-Hung, Lien, Li-Ming
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563105/

Similar Items

Hinokitiol, a Natural Tropolone Derivative, Offers Neuroprotection from Thromboembolic Stroke In Vivo
by: Jayakumar, Thanasekaran, et al.
Published: (2013)

Hinokitiol Induces DNA Damage and Autophagy followed by Cell Cycle Arrest and Senescence in Gefitinib-Resistant Lung Adenocarcinoma Cells
by: Li, Lan-Hui, et al.
Published: (2014)

Concanavalin A potentiates syngeneic response in murine lymphocytes
Published: (1976)

Ectogalactosyltransferase studies in fibroblasts and concanavalin A- stimulated lymphocytes
Published: (1976)

Hinokitiol Inhibits Melanogenesis via AKT/mTOR Signaling in B16F10 Mouse Melanoma Cells
by: Tsao, Yu-Tzu, et al.
Published: (2016)

Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo
by: Lin, Kuan-Hung, et al.
Published: (2015)

Concanavalin A-mediated activation of antigen-primed lymphocytes into secondary cytotoxic lymphocytes
Published: (1977)

Concanavalin A receptors, immunoglobulins, and theta antigen of the lymphocyte surface. Interactions with concanavalin A and with Cytoplasmic structures
Published: (1975)

Evaluation Physical Characteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol In Vitro
by: Shih, Yin-Hua, et al.
Published: (2014)

Amarogentin, a Secoiridoid Glycoside, Abrogates Platelet Activation through PLCγ2-PKC and MAPK Pathways
by: Yen, Ting-Lin, et al.
Published: (2014)

Analysis of the stimulation-inhibition paradox exhibited by lymphocytes exposed to concanavalin A
Published: (1976)

Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells
by: Lin, Chia-Han, et al.
Published: (2013)

CELL-MEDIATED IMMUNE RESPONSES IN VITRO : I. SUPPRESSION OF THE GENERATION OF CYTOTOXIC LYMPHOCYTES BY CONCANAVALIN A AND CONCANAVALIN A-ACTIVATED SPLEEN CELLS
by: Peavy, Duane L., et al.
Published: (1974)

Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes
by: Maalouf, Katia, et al.
Published: (2011)

Concanavalin A as a Tool
by: Bazill, G. W.
Published: (1977)

T-Lymphocyte precursors. I. Synergy between precursor and mature T lymphocytes in the response to concanavalin A
Published: (1976)

Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets
by: Lee, Ye-Ming, et al.
Published: (2012)

Bioactives and Traditional Herbal Medicine for the Treatment of Cardiovascular/Cerebrovascular Diseases 2015
by: Sheu, Joen-Rong, et al.
Published: (2015)

Bioactives and Traditional Herbal Medicine for the Treatment of Cardiovascular/Cerebrovascular Diseases
by: Sheu, Joen-Rong, et al.
Published: (2014)

Salidroside Attenuates Concanavalin A-Induced Hepatitis via Modulating Cytokines Secretion and Lymphocyte Migration in Mice
by: Hu, Baoji, et al.
Published: (2014)

Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets
by: Chang, Yi, et al.
Published: (2013)

Inhibition of intercellular adhesion by concanavalin A is associated with concanavalin A-mediated redistribution of surface receptors
Published: (1979)

Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms
by: Jayakumar, Thanasekaran, et al.
Published: (2017)

Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice
by: Wang, Chengfen, et al.
Published: (2015)

Hinokitiol protects primary neuron cells against prion peptide-induced toxicity via autophagy flux regulated by hypoxia inducing factor-1
by: Moon, Ji-Hong, et al.
Published: (2016)

Cell cycle arrest is not senescence
by: Blagosklonny, Mikhail V.
Published: (2011)

Xanthohumol induces apoptosis and S phase cell cycle arrest in A549 non-small cell lung cancer cells
by: Yong, Wai Kuan, et al.
Published: (2015)

CONCANAVALIN A BINDING PROTEINS OF LYMPHOID CELL SURFACE
by: Choi, Yong Sung, et al.
Published: (1974)

Posttranslational processing of concanavalin A precursors in jackbean cotyledons
Published: (1986)

LOCALIZATION AND CHARACTERIZATION OF CONCANAVALIN A RECEPTORS IN THE SYNAPTIC CLEFT
by: Cotman, C. W., et al.
Published: (1974)

Studies on the mechanisms of macrophage activation. II. Parasite destruction in macrophages activated by supernates from concanavalin A- stimulated lymphocytes
Published: (1979)

Genetic control of lymphocyte activation: lack of response to low doses of concanavalin A in lipopolysaccharide-nonresponder mice
by: Bick, PH, et al.
Published: (1977)

POKEWEED MITOGEN-, CONCANAVALIN A-, AND PHYTOHEMAGGLUTININ-INDUCED DEVELOPMENT OF CYTOTOXIC EFFECTOR LYMPHOCYTES : AN EVALUATION OF THE MECHANISMS OF T CELL-MEDIATED CYTOTOXICITY
by: Kirchner, Holger, et al.
Published: (1973)

Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes
Published: (1980)

Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors
Published: (1976)

Baicalein Selectively Induces Apoptosis in Activated Lymphocytes and Ameliorates Concanavalin A-Induced Hepatitis in Mice
by: Zhang, Yan, et al.
Published: (2013)

Correction: Baicalein Selectively Induces Apoptosis in Activated Lymphocytes and Ameliorates Concanavalin A-Induced Hepatitis in Mice
Published: (2015)

Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation
by: Chang, Yi, et al.
Published: (2013)

GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice
by: Hao, Yu-E, et al.
Published: (2015)

Preventive Effect of Halofuginone on Concanavalin A-Induced Liver Fibrosis
by: Liang, Jie, et al.
Published: (2013)