Soybean β-Conglycinin Prevents Age-Related Hearing Impairment

Obesity-related complications are associated with the development of age-related hearing impairment. β-Conglycinin (β-CG), one of the main storage proteins in soy, offers multiple health benefits, including anti-obesity and anti-atherosclerotic effects. Here, to elucidate the potential therapeutic a...

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Main Authors:	Tanigawa, Tohru, Shibata, Rei, Kondo, Kazuhisa, Katahira, Nobuyuki, Kambara, Takahiro, Inoue, Yoko, Nonoyama, Hiroshi, Horibe, Yuichiro, Ueda, Hiromi, Murohara, Toyoaki
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562634/

id	pubmed-4562634
recordtype	oai_dc
spelling	pubmed-45626342015-09-10 Soybean β-Conglycinin Prevents Age-Related Hearing Impairment Tanigawa, Tohru Shibata, Rei Kondo, Kazuhisa Katahira, Nobuyuki Kambara, Takahiro Inoue, Yoko Nonoyama, Hiroshi Horibe, Yuichiro Ueda, Hiromi Murohara, Toyoaki Research Article Obesity-related complications are associated with the development of age-related hearing impairment. β-Conglycinin (β-CG), one of the main storage proteins in soy, offers multiple health benefits, including anti-obesity and anti-atherosclerotic effects. Here, to elucidate the potential therapeutic application of β-CG, we investigated the effect of β-CG on age-related hearing impairment. Male wild-type mice (age 6 months) were randomly divided into β-CG-fed and control groups. Six months later, the body weight was significantly lower in β-CG-fed mice than in the controls. Consumption of β-CG rescued the hearing impairment observed in control mice. Cochlear blood flow also increased in β-CG-fed mice, as did the expression of eNOS in the stria vascularis (SV), which protects vasculature. β-CG consumption also ameliorated oxidative status as assessed by 4-HNE staining. In the SV, lipofuscin granules of marginal cells and vacuolar degeneration of microvascular pericytes were decreased in β-CG-fed mice, as shown by transmission electron microscopy. β-CG consumption prevented loss of spiral ganglion cells and reduced the frequencies of lipofuscin granules, nuclear invaginations, and myelin vacuolation. Our observations indicate that β-CG ameliorates age-related hearing impairment by preserving cochlear blood flow and suppressing oxidative stress. Public Library of Science 2015-09-08 /pmc/articles/PMC4562634/ /pubmed/26348726 http://dx.doi.org/10.1371/journal.pone.0137493 Text en © 2015 Tanigawa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tanigawa, Tohru Shibata, Rei Kondo, Kazuhisa Katahira, Nobuyuki Kambara, Takahiro Inoue, Yoko Nonoyama, Hiroshi Horibe, Yuichiro Ueda, Hiromi Murohara, Toyoaki
spellingShingle	Tanigawa, Tohru Shibata, Rei Kondo, Kazuhisa Katahira, Nobuyuki Kambara, Takahiro Inoue, Yoko Nonoyama, Hiroshi Horibe, Yuichiro Ueda, Hiromi Murohara, Toyoaki Soybean β-Conglycinin Prevents Age-Related Hearing Impairment
author_facet	Tanigawa, Tohru Shibata, Rei Kondo, Kazuhisa Katahira, Nobuyuki Kambara, Takahiro Inoue, Yoko Nonoyama, Hiroshi Horibe, Yuichiro Ueda, Hiromi Murohara, Toyoaki
author_sort	Tanigawa, Tohru
title	Soybean β-Conglycinin Prevents Age-Related Hearing Impairment
title_short	Soybean β-Conglycinin Prevents Age-Related Hearing Impairment
title_full	Soybean β-Conglycinin Prevents Age-Related Hearing Impairment
title_fullStr	Soybean β-Conglycinin Prevents Age-Related Hearing Impairment
title_full_unstemmed	Soybean β-Conglycinin Prevents Age-Related Hearing Impairment
title_sort	soybean β-conglycinin prevents age-related hearing impairment
description	Obesity-related complications are associated with the development of age-related hearing impairment. β-Conglycinin (β-CG), one of the main storage proteins in soy, offers multiple health benefits, including anti-obesity and anti-atherosclerotic effects. Here, to elucidate the potential therapeutic application of β-CG, we investigated the effect of β-CG on age-related hearing impairment. Male wild-type mice (age 6 months) were randomly divided into β-CG-fed and control groups. Six months later, the body weight was significantly lower in β-CG-fed mice than in the controls. Consumption of β-CG rescued the hearing impairment observed in control mice. Cochlear blood flow also increased in β-CG-fed mice, as did the expression of eNOS in the stria vascularis (SV), which protects vasculature. β-CG consumption also ameliorated oxidative status as assessed by 4-HNE staining. In the SV, lipofuscin granules of marginal cells and vacuolar degeneration of microvascular pericytes were decreased in β-CG-fed mice, as shown by transmission electron microscopy. β-CG consumption prevented loss of spiral ganglion cells and reduced the frequencies of lipofuscin granules, nuclear invaginations, and myelin vacuolation. Our observations indicate that β-CG ameliorates age-related hearing impairment by preserving cochlear blood flow and suppressing oxidative stress.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562634/
_version_	1613473571844128768

Soybean β-Conglycinin Prevents Age-Related Hearing Impairment

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