Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage

The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging proc...

Full description

Bibliographic Details
Main Authors:	Tomaiuolo, Micol, Katche, Cynthia, Viola, Haydee, Medina, Jorge H.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561985/

id	pubmed-4561985
recordtype	oai_dc
spelling	pubmed-45619852015-09-15 Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage Tomaiuolo, Micol Katche, Cynthia Viola, Haydee Medina, Jorge H. Research Article The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag. Hindawi Publishing Corporation 2015 2015-08-25 /pmc/articles/PMC4561985/ /pubmed/26380116 http://dx.doi.org/10.1155/2015/603672 Text en Copyright © 2015 Micol Tomaiuolo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tomaiuolo, Micol Katche, Cynthia Viola, Haydee Medina, Jorge H.
spellingShingle	Tomaiuolo, Micol Katche, Cynthia Viola, Haydee Medina, Jorge H. Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
author_facet	Tomaiuolo, Micol Katche, Cynthia Viola, Haydee Medina, Jorge H.
author_sort	Tomaiuolo, Micol
title	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_short	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_full	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_fullStr	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_full_unstemmed	Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
title_sort	evidence of maintenance tagging in the hippocampus for the persistence of long-lasting memory storage
description	The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561985/
_version_	1613473362538921984

Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage

Similar Items