Recruitment and activation of the ATM kinase in the absence of DNA damage sensors
Two kinases, ATM and DNA-PKcs, control rapid responses to DNA double-strand breaks (DSBs). The paradigm for ATM control is recruitment and activation by the Mre11–Rad50–NBS1 (MRN) sensor complex, whereas DNA-PKcs requires the sensor Ku (Ku70–Ku80). Using Mus musculus cells harboring targeted mutant...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560612/ |