Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185

Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors. Exportin 1 (XPO1) mediates the nucleocytoplasmic transport of numerous molecules including oncogenic growth-regulating factors, RNAs, and ribosomal...

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Bibliographic Details
Main Authors: Tabe, Yoko, Kojima, Kensuke, Yamamoto, Shinichi, Sekihara, Kazumasa, Matsushita, Hiromichi, Davis, Richard Eric, Wang, Zhiqiang, Ma, Wencai, Ishizawa, Jo, Kazuno, Saiko, Kauffman, Michael, Shacham, Sharon, Fujimura, Tsutomu, Ueno, Takashi, Miida, Takashi, Andreeff, Michael
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560410/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560410/

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