Bioceramic Implant Induces Bone Healing of Cranial Defects

Bioceramic Implant Induces Bone Healing of Cranial Defects

Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate–based implant was developed and previously shown to potentially stimulate bone growth. We here un...

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Main Authors: Engstrand, Thomas, Kihlström, Lars, Lundgren, Kalle, Trobos, Margarita, Engqvist, Håkan, Thomsen, Peter
Format: Online
Language:English
Published: Wolters Kluwer Health 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560224/
id pubmed-4560224
recordtype oai_dc
spelling pubmed-45602242015-10-22 Bioceramic Implant Induces Bone Healing of Cranial Defects Engstrand, Thomas Kihlström, Lars Lundgren, Kalle Trobos, Margarita Engqvist, Håkan Thomsen, Peter Case Report Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate–based implant was developed and previously shown to potentially stimulate bone growth. We here uncover evidence of induced bone formation in 2 patients. Histological examination 9 months postoperatively showed multinuclear cells in the central defect zone and bone ingrowth in the bone-implant border zone. An increased expression of bone-associated markers was detected. The other patient was investigated 50 months postoperatively. Histological examination revealed ceramic materials covered by vascularized compact bone. The bone regenerative effect induced by the implant may potentially improve long-term clinical outcome compared with conventional techniques, which needs to be verified in a clinical study. Wolters Kluwer Health 2015-08-25 /pmc/articles/PMC4560224/ /pubmed/26495204 http://dx.doi.org/10.1097/GOX.0000000000000467 Text en Copyright © 2015 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Engstrand, Thomas
Kihlström, Lars
Lundgren, Kalle
Trobos, Margarita
Engqvist, Håkan
Thomsen, Peter
spellingShingle Engstrand, Thomas
Kihlström, Lars
Lundgren, Kalle
Trobos, Margarita
Engqvist, Håkan
Thomsen, Peter
Bioceramic Implant Induces Bone Healing of Cranial Defects
author_facet Engstrand, Thomas
Kihlström, Lars
Lundgren, Kalle
Trobos, Margarita
Engqvist, Håkan
Thomsen, Peter
author_sort Engstrand, Thomas
title Bioceramic Implant Induces Bone Healing of Cranial Defects
title_short Bioceramic Implant Induces Bone Healing of Cranial Defects
title_full Bioceramic Implant Induces Bone Healing of Cranial Defects
title_fullStr Bioceramic Implant Induces Bone Healing of Cranial Defects
title_full_unstemmed Bioceramic Implant Induces Bone Healing of Cranial Defects
title_sort bioceramic implant induces bone healing of cranial defects
description Autologous bone or inert alloplastic materials used in cranial reconstructions are techniques that are associated with resorption, infection, and implant exposure. As an alternative, a calcium phosphate–based implant was developed and previously shown to potentially stimulate bone growth. We here uncover evidence of induced bone formation in 2 patients. Histological examination 9 months postoperatively showed multinuclear cells in the central defect zone and bone ingrowth in the bone-implant border zone. An increased expression of bone-associated markers was detected. The other patient was investigated 50 months postoperatively. Histological examination revealed ceramic materials covered by vascularized compact bone. The bone regenerative effect induced by the implant may potentially improve long-term clinical outcome compared with conventional techniques, which needs to be verified in a clinical study.
publisher Wolters Kluwer Health
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560224/
_version_ 1613472873444278272

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