MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis

MicroRNA-214 regulates both angiogenic function in endothelial cells and apoptosis in various cancers. However, the regulation and function of miR-214 is unclear in canine hemangiosarcoma, which is a spontaneous model of human angiosarcoma. The expression and functional roles of miR-214 in canine he...

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Bibliographic Details
Main Authors: Heishima, Kazuki, Mori, Takashi, Sakai, Hiroki, Sugito, Nobuhiko, Murakami, Mami, Yamada, Nami, Akao, Yukihiro, Maruo, Kohji
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559432/