Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury

Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury

Excitotoxicity following cerebral ischemia elicits a molecular cascade, which leads to neuronal death. c-Jun-N-terminal kinase (JNK) has a key role in excitotoxic cell death. We have previously shown that JNK inhibition by a specific cell-permeable peptide significantly reduces infarct size and neur...

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Bibliographic Details
Main Authors: Vercelli, A, Biggi, S, Sclip, A, Repetto, I E, Cimini, S, Falleroni, F, Tomasi, S, Monti, R, Tonna, N, Morelli, F, Grande, V, Stravalaci, M, Biasini, E, Marin, O, Bianco, F, di Marino, D, Borsello, T
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558515/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558515/

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