Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Schistosomal egg antigens induce host bile ductular cells to proliferate and produce osteopontin (OPN), a pro-fibrogenic factor that stimulates hepatic stellate cells to become myofibroblasts. The numbers of OPN-producing bile ductules correlate with fibrogenesis and portal hypertension in humans an...

Full description

Bibliographic Details
Main Authors: Pereira, Thiago A., Syn, Wing-Kin, Machado, Mariana V., Vidigal, Paula V., Resende, Vivian, Voieta, Izabela, Xie, Guanhua, Otoni, Alba, Souza, Márcia M., Santos, Elisângela T., Chan, Isaac S., Trindade, Guilherme V.M., Choi, Steve S., Witek, Rafal P., Pereira, Fausto E., Secor, William E., Andrade, Zilton A., Lambertucci, José Roberto, Diehl, Anna Mae
Format: Online
Language:English
Published: Portland Press Ltd. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558314/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558314/

Similar Items